Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver

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Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver

BACKGROUND Hyperglycemia induces chromatin remodeling with consequences on differential gene expression in mouse hepatocytes, similar to what occurs during aging. The liver is the central organ for the regulation of glucose homeostasis and xenobiotic and lipid metabolism and is affected by insulin signaling. The precise transcriptional profiling of the type-1 diabetic liver and its comparison t...

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ژورنال

عنوان ژورنال: BMC Endocrine Disorders

سال: 2014

ISSN: 1472-6823

DOI: 10.1186/1472-6823-14-19